Ganetespib radiosensitization for liver cancer therapy
نویسندگان
چکیده
منابع مشابه
Ganetespib radiosensitization for liver cancer therapy
Therapies for liver cancer particularly those including radiation are still inadequate. Inhibiting the stress response machinery is an appealing anti-cancer and radiosensitizing therapeutic strategy. Heat-shock-protein-90 (HSP90) is a molecular chaperone that is a prominent effector of the stress response machinery and is overexpressed in liver cancer cells. HSP90 client proteins include critic...
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PURPOSE HSP90 inhibition is well known to sensitize cancer cells to radiation. However, it is currently unknown whether additional radiosensitization could occur in the more clinically relevant setting of chemoradiation (CRT). We used the potent HSP90 inhibitor ganetespib to determine whether it can enhance CRT effects in NSCLC. EXPERIMENTAL DESIGN We first performed in vitro experiments in v...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2016
ISSN: 1538-4047,1555-8576
DOI: 10.1080/15384047.2016.1156258